2008二月 iHut 講座

演講者：謝世良教授 (國立陽明大學微生物免疫學研究中心主任)

題目：免疫系統與腫瘤細胞之交互作用

時間：2008年2月24日，星期日，下午四點

地點：謝老師家 

免疫學之重要主題為如何區分外來及自我之抗原。然而宿主要如何在抗體生成及T細胞反應前辨識外來抗原仍是未解之謎題。在免疫細胞上有許許多多的凝集素受體可辨識醣類構造，然而其功能尚未被全盤研究。醣化是後轉譯修飾中較普遍且複雜之機制，而致病原及癌細胞上之多醣體對於免疫細胞如何辨識及疫苗發展相當重要。2003年爆發的SARS疫情使我對宿主細胞如何辨識第一次接觸之新的致病原感到興趣。為了解決此問題，我們發展出一技術平台來辨識病毒及其他致病原表面上之可能ligand，並得到中草藥之醣組成特徵，我們正進一步探究及討論其在疫苗及藥物發展之可能性。

謝世良教授畢業於國立陽明大學醫學系(放射腫瘤科醫師)，考取台灣教育部公費留學獎學金至英國牛津大學攻讀生化免疫學博士學位，並接受Johnson & Johnson’s fellowship 而至 Stanford University Medical School 與 Professor Hugh O. McDevitt 從事博士後研究。於1994年返回台灣後一直在國立陽明大學任教並兼任台北榮民總醫院醫師，曾擔任國立陽明大學微生物暨免疫學所所長、醫學系副系主任、奇美醫院醫學中心顧問、台北市立聯合醫院教學研究部主任，國家衛生研究院疫苗中心聘任為合聘研究員，並於2005年應翁啟惠主任邀聘為中央研究院基因體中心合聘研究員。現任國立陽明大學及台北榮民總醫院免疫學中心主任。

Speaker: Professor Shie-Liang Hsieh (Director, Immunology Research Center, National Yang-Ming University, Taiwan)

Date and Time: February 24, Sunday, 4PM

Place:  謝老師家 (Dr. Hsieh's House)

Topic Title: Glycoimmunology: An Emerging Discipline in Host-Pathogen Interaction

The central theme of immunology is the differentiation of self antigen from non-self antigen. However, how host recognizes foreign antigen in the first encounter, especially before the production of antibody and T cell response, is an unsolved mystery. There are abundant of lectin receptors, which are able to recognize the structure of glycans, expressed on the surface of immune cells, but their functions are not investigated systemically yet. Glycosylation is one of the more common and complex post-translational modification, and polysaccharides of pathogens and cancer cells are important for immune cell recognition and vaccine development. The SARS attack in year 2003 raise me the curiosity how host cells can recognize such a novel pathogen in the first contact. To solve out this problem, a platform technology is developed to identify their potential ligands on the surface of viruses and other pathogens, and to obtain the fingerprinting of the sugar components of Chinese herbal drugs.  Its potential in vaccine and drug development in under intensive investigation now.

Shie-Liang Hsieh, born in Taipei, Taiwan, received his M.D. degree at the National Yang-Ming University (1984), and Ph.D. degree in immunology and biochemistry at University of Oxford, United Kingdom (1992). Under the fellowship support of Johnson & Johnson, he spent one year in 1993 as a postdoctoral fellow at Stanford University where he worked with Professor Hugh O. McDevitt of Stanford University Medical School. Since then Professor Hsieh has been since teaching and researching in the field of immunology and biochemistry, and is now Director of Immunology Research center at the National Yang-Ming University. His research accomplishments have been recognized by the National Science Council of Taiwan, 1999 and 2003, among many teaching and researching awards he has received. Currently Professor Hsieh is also a joint appointment research fellow with the Genomics Research Center at the Academic Sinica of Taiwan.